ADULT
INTESTINAL TOXAEMIA BOTULISM IN ULCERATIVE COLITIS PATIENT
*Authors ElSagad Eltayeb 1,2, Afrah E.
Mohammed 3, Aisha Alrajhi3, Enass M.
Abdalla4, Nassir Alhaboob Arabi1, Sanaa A. Abdelaziz5,
and Kamal H. Eltom4
Received 20 September
2023
Accepted for publication 10 November 2023
Published 19 December 2023
Volume 1:1 Pages 17—21
Checked for plagiarism Yes
Peer reviewer comments 2
1 Ibn Sina Specialised Hospital, Alamarat, Street 17–21,
12217 Khartoum, Sudan; sagadgady@yahoo.com (E.E.), nassir_alhaboob@yahoo.com (N.A.A).
2 Faculty of Medicine, Al Neelain University, Street 53,
11111 Khartoum, Sudan
3 Department of Biology, College of
Science, Princess Nourah bint Abdulrahman University, Riyadh P.O. Box 84428,
Riyadh,11671, Saudi Arabia;
afamohammed@pnu.edu.sa
4 Department of Animal Health and Safety of Animal
Products, Institute for Studies and Promotion of Animal Exports, University of
Khartoum, Shambat 13314, Khartoum North, Sudan; kamal@uofk.edu (K.H.E.);
enassmukh17@gmail.com (E.M.A.)
5 Department of Microbiology, Faculty of Veterinary
Medicine, University of Khartoum, Shambat 13314, Khartoum North, Sudan; sabdelaziz262@gmail.com
Correspondence: keltom@gwdg.de*
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Abstract
Botulism
is caused by neurotoxins produced by diverse members of the genus Clostridium
and is rare in humans. Among the major forms is the adult intestinal toxaemia
botulism caused by the in situ production of the neurotoxin from the toxigenic Clostridium
spp. colonizing the intestines. Crohn's disease an inflammatory bowel disease,
(IBD) is considered a predisposing factor for colonization of the intestines by
C. botulinum. Here, we report the first case of botulism in a patient
with ulcerative colitis (UC) who visited the gastrointestinal clinic
complaining of intermittent diarrhea, abdominal distension, and acute pain. In
addition, she experienced symptoms of cranial nerve palsies) diplopia and
blurred vision (that lasted for a short time. C. botulinum was isolated
from the stool of the patient, which led to the confirmed diagnosis of adult
intestinal toxaemia botulism. Long antibiotic therapy and UC (another form of
IBD) had likely promoted colonization by C. botulinum, leading to the
symptoms of botulism that were overlooked by those of UC
Keywords: Botulinum
neurotoxins, Clostridium sp., inflammatory bowel disease, gastrointestinal disease
